Novel Silane Crosslinked Chitosan Based Electrospun Nanofiber for Controlled Release of Benzocaine

Nanofibers mats of chitosan (CTS)/polyvinyl alcohol (PVA)/halloysite nanoclay and drug loaded CTS/PVA/halloysite nanoclay//3-glycidyoxypropyl trimethoxysilane were fabricated using the electrospinning method. Electrospun nanofiber samples characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), thermogravimetric analysis (TGA). FTIR confirmed chemical physical bonding among ingredients such as CTS, PVA, crosslinker in nanofibers. SEM images showed development uniform The average diameter was observed range 50–200 nm. Antimicrobial activity examined against E. coli S. aurus bacteria. results obtained indicated that all significant antimicrobial Gram-positive well Gram-negative TGA thermal stability nanofibers increased with addition crosslinker. release studied phosphate buffer saline (PBS) solution (pH 7.4) at 37°C released from 2.5 h. Hence, these prepared can be used medication where is required for a long duration.